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KMID : 0378619960130010087
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Baptist Hospital Medical Journal
1996 Volume.13 No. 1 p.87 ~ p.95
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Incidence of Cough and Changes in Urinary Microalbumin Excretion and Serum Lipid Levels after Lisinopril Administration
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Abstract
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Background:
@EN The objectives of this study were to 1) evaluate the incidence and characteristics of lisinopril related cough in Korean patients with mild to moderate essential hypertension, and to 2) determine the effect of long-term lisinopril
administration on
blood pressure urinary microalbumin excretion and serum lipid levels.
@ES Methods:
@EN Forty five patients were included in the beginning of this study, but 7 patients were dropped out After a washout period over 1 week, lisinopril 10-20mg was given once daily. Blood pressure, heart rate and cough were checked before and after
oral
administration of lisinopril at 2 ro 4 week interval. Urinary microalbumin excretion and serum lipid levels were evaluated before and after lisinopril administration(week 4, week 12, week 20).
@ES Results:
@EN Lisinopril reduced blood pressure from 169/105mmHg to 133/87mmHg at the end of 20-week treatment and exhibited the overall effective rate of 93%. Heart rate was not affected With lisinopril treatment cough was observed in 25 patients(66%).
The
major
characteristics of lisinopril related cough was dry(68%). Intermittent(92%) and occurred during day and night. Sixteen patients(64%) developed cough within one week after lisinopril adminstration, 4 patients(16%) developed about 2 week after
administration, and 5 patients(20%) developed 4 week after administration, Urinary microalbumin excretion was significantly reduced at 12 week and this reduction was maintained until the end of the study, whereas urinary macroalbumin excretion
was
not
Total cholesterol and HDL-cholesterol levels were slightly lowered by lisinopril at 20 weeks, but LDL-cholesterol and triglyceride levels were not. However, the number of patients with LDL-cholesterol below 130mg/dL was increased from 59% to 85%
at
the
end of stydy.
@ES Conclusion:
@EN In Korean patients with mild to moderate essential hypertension, lisinopril exhibited beneficial effects on urinary microalbumin excretion rate and serum lipid levels, which have been reported with other ACE inhibitors. Lisinopril also
exhibited
similar incidence of cough to that of other ACE inhibitors.
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KEYWORD
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